null

SMILES: COC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(C)c2)nc1

InChI Key: InChIKey=VCHHZXZFRONTDH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 374968   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Wnt-3a (Homo sapiens (Human))	BDBM374968 (US10251893, Cpd 166) Show SMILES COC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(C)c2)nc1 Show InChI InChI=1S/C25H28N6O3/c1-17-12-19(15-28-24(17)20-6-7-26-18(2)13-20)14-23(32)29-22-5-4-21(16-27-22)30-8-10-31(11-9-30)25(33)34-3/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,27,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...				J Med Chem 50: 5727-34 (2007) BindingDB Entry DOI: 10.7270/Q2GM89KJ
					More data for this Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine (Mus musculus)	BDBM374968 (US10251893, Cpd 166) Show SMILES COC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(C)c2)nc1 Show InChI InChI=1S/C25H28N6O3/c1-17-12-19(15-28-24(17)20-6-7-26-18(2)13-20)14-23(32)29-22-5-4-21(16-27-22)30-8-10-31(11-9-30)25(33)34-3/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,27,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...				ACS Med Chem Lett 7: 676-80 (2016) Article DOI: 10.1021/acsmedchemlett.6b00038
					More data for this Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine (Mus musculus)	BDBM374968 (US10251893, Cpd 166) Show SMILES COC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(C)c2)nc1 Show InChI InChI=1S/C25H28N6O3/c1-17-12-19(15-28-24(17)20-6-7-26-18(2)13-20)14-23(32)29-22-5-4-21(16-27-22)30-8-10-31(11-9-30)25(33)34-3/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,27,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...				ACS Med Chem Lett 7: 676-80 (2016) Article DOI: 10.1021/acsmedchemlett.6b00038
					More data for this Ligand-Target Pair