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SMILES: CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(-c3ccnc(C)c3)c(c2)C#N)nc1

InChI Key: InChIKey=QTCBPVQIDFRGAV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374993   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Wnt-3a


(Homo sapiens (Human))		BDBM374993
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-cy...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(-c3ccnc(C)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C25H25N7O2/c1-17-11-20(5-6-27-17)25-21(14-26)12-19(15-29-25)13-24(34)30-23-4-3-22(16-28-23)32-9-7-31(8-10-32)18(2)33/h3-6,11-12,15-16H,7-10,13H2,1-2H3,(H,28,30,34)
PDB

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KEGG

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



St. Jude Research Hospital



Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...

J Med Chem 50: 5727-34 (2007)


BindingDB Entry DOI: 10.7270/Q2GM89KJ
More data for this
Ligand-Target Pair