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SMILES: CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(F)c2)-c2ccnc(C)c2)nc1

InChI Key: InChIKey=RBLYPWNZMHDDJD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374995   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Wnt-3a


(Homo sapiens (Human))		BDBM374995
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-fl...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(F)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C24H25FN6O2/c1-16-11-19(5-6-26-16)24-21(25)12-18(14-28-24)13-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11-12,14-15H,7-10,13H2,1-2H3,(H,27,29,33)
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PC cid
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UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



St. Jude Research Hospital



Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...

J Med Chem 50: 5727-34 (2007)


BindingDB Entry DOI: 10.7270/Q2GM89KJ
More data for this
Ligand-Target Pair