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SMILES: C[C@H](Nc1nccc(N2CCOC2=O)c1C)c1cc2cc(Cl)ccc2[nH]c1=O

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 375155   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]


(Homo sapiens (Human))		BDBM375155
PNG
(6-chloro-3-[(1S)-1-{[3- | US10253015, Compound I-1...)
Show SMILES C[C@H](Nc1nccc(N2CCOC2=O)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|
PDB

UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Vanderbilt University School of Medicine



Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...

Proc Natl Acad Sci U S A 97: 925-30 (2000)


BindingDB Entry DOI: 10.7270/Q23F4S02
More data for this
Ligand-Target Pair