BDBM375218 5-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-78

SMILES: Clc1ccc2[nH]c(=O)c(CNc3ccc(nc3)C#N)cc2c1

InChI Key: InChIKey=WGKDYBHVCHZYSW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 375218   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
IDH1 R132H (Homo sapiens (Human))	BDBM375218 (5-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3- | US102...) Show SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc(nc3)C#N)cc2c1 Show InChI InChI=1S/C16H11ClN4O/c17-12-1-4-15-10(6-12)5-11(16(22)21-15)8-19-14-3-2-13(7-18)20-9-14/h1-6,9,19H,8H2,(H,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine					Assay Description Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...				Proc Natl Acad Sci U S A 97: 925-30 (2000) BindingDB Entry DOI: 10.7270/Q23F4S02
					More data for this Ligand-Target Pair