BDBM375221 6-{[(6-methoxy-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-81

SMILES: COc1ccc2[nH]c(=O)c(CNc3ccc(cn3)C#N)cc2c1

InChI Key: InChIKey=VVWRUKYUZPANQP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 375221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
IDH1 R132H (Homo sapiens (Human))	BDBM375221 (6-{[(6-methoxy-2-oxo-1,2-dihydroquinolin-3- | US10...) Show SMILES COc1ccc2[nH]c(=O)c(CNc3ccc(cn3)C#N)cc2c1 Show InChI InChI=1S/C17H14N4O2/c1-23-14-3-4-15-12(7-14)6-13(17(22)21-15)10-20-16-5-2-11(8-18)9-19-16/h2-7,9H,10H2,1H3,(H,19,20)(H,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine					Assay Description Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...				Proc Natl Acad Sci U S A 97: 925-30 (2000) BindingDB Entry DOI: 10.7270/Q23F4S02
					More data for this Ligand-Target Pair