null

SMILES: Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1

InChI Key: InChIKey=WBJOOHAZLNMRLC-BJMVGYQFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 375734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM375734 (US10301323, Compound B4 | US9908899, Compound B4) Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...				J Med Chem 50: 685-95 (2007) BindingDB Entry DOI: 10.7270/Q2736T75
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM375734 (US10301323, Compound B4 | US9908899, Compound B4) Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...				J Med Chem 50: 685-95 (2007) BindingDB Entry DOI: 10.7270/Q2736T75
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM375734 (US10301323, Compound B4 | US9908899, Compound B4) Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...				J Med Chem 49: 1202-6 (2006) BindingDB Entry DOI: 10.7270/Q2JD504D
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM375734 (US10301323, Compound B4 | US9908899, Compound B4) Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...				J Med Chem 49: 1202-6 (2006) BindingDB Entry DOI: 10.7270/Q2JD504D
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM375734 (US10301323, Compound B4 | US9908899, Compound B4) Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...				J Med Chem 49: 1202-6 (2006) BindingDB Entry DOI: 10.7270/Q2JD504D
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM375734 (US10301323, Compound B4 | US9908899, Compound B4) Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1 Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...				J Med Chem 50: 685-95 (2007) BindingDB Entry DOI: 10.7270/Q2736T75
					More data for this Ligand-Target Pair