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SMILES: Cn1nnnc1Cc1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1

InChI Key: InChIKey=UHUYZOHASDYVNA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376108   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM376108
PNG
(2-fluoro-N-(1-(4- fluorophenyl)-3-((1-methyl- 1H-t...)
Show SMILES Cn1nnnc1Cc1cc(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)n(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H16F5N9O/c1-37-21(33-35-36-37)10-14-9-20(38(34-14)15-5-3-13(25)4-6-15)32-23(39)17-11-16(22-30-7-2-8-31-22)18(12-19(17)26)24(27,28)29/h2-9,11-12H,10H2,1H3,(H,32,39)
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



University of Namur



Assay Description
 In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...

J Med Chem 51: 3077-80 (2008)


BindingDB Entry DOI: 10.7270/Q2WQ0629
More data for this
Ligand-Target Pair