null

SMILES: CN(C(=O)Oc1ccc(NC(=O)c2nn(N3CN(CC=C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1)c1ccccc1

InChI Key: InChIKey=UHTLWSJRYBKFIF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376980   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM376980 ((R)-4-(1-(1-acryloylpyrimidin-3-yl)-4-amino-1H-pyr...) Show SMILES CN(C(=O)Oc1ccc(NC(=O)c2nn(N3CN(CC=C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1)c1ccccc1 |c:19| Show InChI InChI=1S/C28H27N9O4/c1-4-22(38)35-13-8-14-36(17-35)37-26-23(25(29)30-16-31-26)24(33-37)27(39)32-21-12-11-20(15-18(21)2)41-28(40)34(3)19-9-6-5-7-10-19/h4-12,14-16H,1,13,17H2,2-3H3,(H,32,39)(H2,29,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile...				US Patent US10329300 (2019) BindingDB Entry DOI: 10.7270/Q2MG7RWF
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM376980 ((R)-4-(1-(1-acryloylpyrimidin-3-yl)-4-amino-1H-pyr...) Show SMILES CN(C(=O)Oc1ccc(NC(=O)c2nn(N3CN(CC=C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1)c1ccccc1 |c:19| Show InChI InChI=1S/C28H27N9O4/c1-4-22(38)35-13-8-14-36(17-35)37-26-23(25(29)30-16-31-26)24(33-37)27(39)32-21-12-11-20(15-18(21)2)41-28(40)34(3)19-9-6-5-7-10-19/h4-12,14-16H,1,13,17H2,2-3H3,(H,32,39)(H2,29,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Universite Paris 7-Denis Diderot					Assay Description For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...				Bioorg Med Chem 16: 1242-53 (2008) BindingDB Entry DOI: 10.7270/Q2BR8VHD
					More data for this Ligand-Target Pair