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SMILES: N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12

InChI Key: InChIKey=UXWYEGHVHSYQJL-NSHDSACASA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 377148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377148 (5-Amino-N-{7-[(3S)-3-aminopiperidin-1-yl]thieno[3,...) Show SMILES N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnc2ccsc12 |r| Show InChI InChI=1S/C22H20F2N6OS2/c23-12-4-1-5-13(24)16(12)22-29-17(20(26)33-22)21(31)28-15-9-27-14-6-8-32-19(14)18(15)30-7-2-3-11(25)10-30/h1,4-6,8-9,11H,2-3,7,10,25-26H2,(H,28,31)/t11-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair