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SMILES: N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F

InChI Key: InChIKey=QLLAOUOYSHXDOH-STQMWFEESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 377164   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377164 (US10265307, Example 18-2 | US10517858, Example 18 ...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair