BDBM377166 US10265307, Example 19-2::US10517858, Example 19 (Diastereoisomer 2)::US10828290, Example 19 (Diastereoisomer 1)

SMILES: C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1

InChI Key: InChIKey=JEGQLROZFGAUST-FNODVLLQSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 377166   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM377166 (US10265307, Example 19-2 | US10517858, Example 19 ...) Show SMILES C[C@@]1(O)CCc2c1ncc(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)c2N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26F2N6O2S/c1-24(34)8-7-13-19(32-9-3-4-12(27)11-32)16(10-29-20(13)24)30-22(33)18-21(28)35-23(31-18)17-14(25)5-2-6-15(17)26/h2,5-6,10,12,34H,3-4,7-9,11,27-28H2,1H3,(H,30,33)/t12-,24+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair