BDBM377437 5-((S)-3-(But-2-ynamido)piperidin-1-yl)-6-fluoro-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (Racemic)::US10266491, Example 130

SMILES: CC#CC(=O)N[C@H]1CCCN(C1)c1c2C3CCC(CC3Nc2c(cc1F)C(N)=O)C(C)(C)O

InChI Key: InChIKey=RLZKVDNHVSOPDD-WMUKIEHLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 377437   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM377437 (5-((S)-3-(But-2-ynamido)piperidin-1-yl)-6-fluoro-2...) Show SMILES CC#CC(=O)N[C@H]1CCCN(C1)c1c2C3CCC(CC3Nc2c(cc1F)C(N)=O)C(C)(C)O |r| Show InChI InChI=1S/C25H33FN4O3/c1-4-6-20(31)28-15-7-5-10-30(13-15)23-18(26)12-17(24(27)32)22-21(23)16-9-8-14(25(2,3)33)11-19(16)29-22/h12,14-16,19,29,33H,5,7-11,13H2,1-3H3,(H2,27,32)(H,28,31)/t14?,15-,16?,19?/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q26112M3
					More data for this Ligand-Target Pair