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SMILES: FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1

InChI Key: InChIKey=DPYZQKALUJGSGL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 379323   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379323 (N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1 Show InChI InChI=1S/C16H14F3N5/c17-16(18,19)12-8-21-15(24-14(12)22-10-1-2-10)23-11-3-4-13-9(7-11)5-6-20-13/h3-8,10,20H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...				Bioorg Med Chem 16: 4963-83 (2008) BindingDB Entry DOI: 10.7270/Q2N30084
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379323 (N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1 Show InChI InChI=1S/C16H14F3N5/c17-16(18,19)12-8-21-15(24-14(12)22-10-1-2-10)23-11-3-4-13-9(7-11)5-6-20-13/h3-8,10,20H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379323 (N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1 Show InChI InChI=1S/C16H14F3N5/c17-16(18,19)12-8-21-15(24-14(12)22-10-1-2-10)23-11-3-4-13-9(7-11)5-6-20-13/h3-8,10,20H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379323 (N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3[nH]ccc3c2)nc1NC1CC1 Show InChI InChI=1S/C16H14F3N5/c17-16(18,19)12-8-21-15(24-14(12)22-10-1-2-10)23-11-3-4-13-9(7-11)5-6-20-13/h3-8,10,20H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY US Patent					Assay Description ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...				US Patent US10774092 (2020)
					More data for this Ligand-Target Pair