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SMILES: FC(F)(F)c1cnc(Nc2ccc3OCOc3c2)nc1NC1CC1

InChI Key: InChIKey=OQZYXPQQYVKTSZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 379332   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379332 (N2-(benzo[d][1,3]dioxol-5-yl)-N4-cyclopropyl-5-(tr...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OCOc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H13F3N4O2/c16-15(17,18)10-6-19-14(22-13(10)20-8-1-2-8)21-9-3-4-11-12(5-9)24-7-23-11/h3-6,8H,1-2,7H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...				Bioorg Med Chem 16: 4963-83 (2008) BindingDB Entry DOI: 10.7270/Q2N30084
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379332 (N2-(benzo[d][1,3]dioxol-5-yl)-N4-cyclopropyl-5-(tr...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OCOc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H13F3N4O2/c16-15(17,18)10-6-19-14(22-13(10)20-8-1-2-8)21-9-3-4-11-12(5-9)24-7-23-11/h3-6,8H,1-2,7H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00873 BindingDB Entry DOI: 10.7270/Q2TX3K0J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379332 (N2-(benzo[d][1,3]dioxol-5-yl)-N4-cyclopropyl-5-(tr...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OCOc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H13F3N4O2/c16-15(17,18)10-6-19-14(22-13(10)20-8-1-2-8)21-9-3-4-11-12(5-9)24-7-23-11/h3-6,8H,1-2,7H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00873 BindingDB Entry DOI: 10.7270/Q2TX3K0J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379332 (N2-(benzo[d][1,3]dioxol-5-yl)-N4-cyclopropyl-5-(tr...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OCOc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H13F3N4O2/c16-15(17,18)10-6-19-14(22-13(10)20-8-1-2-8)21-9-3-4-11-12(5-9)24-7-23-11/h3-6,8H,1-2,7H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY US Patent					Assay Description ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...				US Patent US10774092 (2020) BindingDB Entry DOI: 10.7270/Q24F1TTD
					More data for this Ligand-Target Pair