BDBM379374 2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenol::US10266549, Example 255::US10774092, Example 255
SMILES: Oc1ccccc1Nc1ncc(c(NC2CC2)n1)C(F)(F)F
InChI Key: InChIKey=COLGXIYXWMDAJV-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human)) | BDBM379374 (2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimi...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences | Assay Description Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20... | Bioorg Med Chem 16: 4963-83 (2008) BindingDB Entry DOI: 10.7270/Q2N30084 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human)) | BDBM379374 (2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimi...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 6.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human)) | BDBM379374 (2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimi...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human)) | BDBM379374 (2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimi...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY US Patent | Assay Description ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,... | US Patent US10774092 (2020) | |||||||||||
More data for this Ligand-Target Pair |