BDBM379406 US10266549, Example 304a::US10774092, Example 304a

SMILES: Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1

InChI Key: InChIKey=XWPNWIGEIJKOEC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 379406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379406 (US10266549, Example 304a | US10774092, Example 304...) Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...				Bioorg Med Chem 16: 4963-83 (2008) BindingDB Entry DOI: 10.7270/Q2N30084
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379406 (US10266549, Example 304a | US10774092, Example 304...) Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY US Patent					Assay Description ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...				US Patent US10774092 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK2 (Homo sapiens (Human))	BDBM379406 (US10266549, Example 304a | US10774092, Example 304...) Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379406 (US10266549, Example 304a | US10774092, Example 304...) Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	679	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK2 (Homo sapiens (Human))	BDBM379406 (US10266549, Example 304a | US10774092, Example 304...) Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379406 (US10266549, Example 304a | US10774092, Example 304...) Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair