null

SMILES: CC(CC1(NC(=O)NC1=O)C1CCOCC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=DZKDNSLWNWXEJQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 379675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379675 (US9926281, Compound 199) Show SMILES CC(CC1(NC(=O)NC1=O)C1CCOCC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C22H28Cl2N4O4/c1-14(13-22(15-2-8-32-9-3-15)20(30)25-21(31)26-22)19(29)28-6-4-27(5-7-28)18-11-16(23)10-17(24)12-18/h10-12,14-15H,2-9,13H2,1H3,(H2,25,26,30,31)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379675 (US9926281, Compound 199) Show SMILES CC(CC1(NC(=O)NC1=O)C1CCOCC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C22H28Cl2N4O4/c1-14(13-22(15-2-8-32-9-3-15)20(30)25-21(31)26-22)19(29)28-6-4-27(5-7-28)18-11-16(23)10-17(24)12-18/h10-12,14-15H,2-9,13H2,1H3,(H2,25,26,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM379675 (US9926281, Compound 199) Show SMILES CC(CC1(NC(=O)NC1=O)C1CCOCC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C22H28Cl2N4O4/c1-14(13-22(15-2-8-32-9-3-15)20(30)25-21(31)26-22)19(29)28-6-4-27(5-7-28)18-11-16(23)10-17(24)12-18/h10-12,14-15H,2-9,13H2,1H3,(H2,25,26,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM379675 (US9926281, Compound 199) Show SMILES CC(CC1(NC(=O)NC1=O)C1CCOCC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C22H28Cl2N4O4/c1-14(13-22(15-2-8-32-9-3-15)20(30)25-21(31)26-22)19(29)28-6-4-27(5-7-28)18-11-16(23)10-17(24)12-18/h10-12,14-15H,2-9,13H2,1H3,(H2,25,26,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM379675 (US9926281, Compound 199) Show SMILES CC(CC1(NC(=O)NC1=O)C1CCOCC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C22H28Cl2N4O4/c1-14(13-22(15-2-8-32-9-3-15)20(30)25-21(31)26-22)19(29)28-6-4-27(5-7-28)18-11-16(23)10-17(24)12-18/h10-12,14-15H,2-9,13H2,1H3,(H2,25,26,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair