null

SMILES: COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C

InChI Key: InChIKey=DATNVJMWIKFHGB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 381020   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM381020 (US9890185, Example 15(j)) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C Show InChI InChI=1S/C36H38N7O4P/c1-21-16-24(17-22-20-38-43-32(21)22)39-34-37-15-14-31(42-34)47-29-13-12-27(25-10-8-9-11-26(25)29)40-35(44)41-28-18-23(36(2,3)4)19-30(33(28)46-5)48(6,7)45/h8-20H,1-7H3,(H,38,43)(H,37,39,42)(H2,40,41,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	173	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM381020 (US9890185, Example 15(j)) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C Show InChI InChI=1S/C36H38N7O4P/c1-21-16-24(17-22-20-38-43-32(21)22)39-34-37-15-14-31(42-34)47-29-13-12-27(25-10-8-9-11-26(25)29)40-35(44)41-28-18-23(36(2,3)4)19-30(33(28)46-5)48(6,7)45/h8-20H,1-7H3,(H,38,43)(H,37,39,42)(H2,40,41,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	855	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 1: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining ...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM381020 (US9890185, Example 15(j)) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C Show InChI InChI=1S/C36H38N7O4P/c1-21-16-24(17-22-20-38-43-32(21)22)39-34-37-15-14-31(42-34)47-29-13-12-27(25-10-8-9-11-26(25)29)40-35(44)41-28-18-23(36(2,3)4)19-30(33(28)46-5)48(6,7)45/h8-20H,1-7H3,(H,38,43)(H,37,39,42)(H2,40,41,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM381020 (US9890185, Example 15(j)) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C)c5[nH]ncc5c4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C Show InChI InChI=1S/C36H38N7O4P/c1-21-16-24(17-22-20-38-43-32(21)22)39-34-37-15-14-31(42-34)47-29-13-12-27(25-10-8-9-11-26(25)29)40-35(44)41-28-18-23(36(2,3)4)19-30(33(28)46-5)48(6,7)45/h8-20H,1-7H3,(H,38,43)(H,37,39,42)(H2,40,41,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair