null

SMILES: COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1

InChI Key: InChIKey=PDRRMIHGJSJJLS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 381150   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM381150 (3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1 Show InChI InChI=1S/C42H48N6O7S2/c1-42(2,3)28-23-35(39(54-5)37(24-28)56(6)51)47-41(50)46-34-11-12-36(33-10-8-7-9-32(33)34)55-30-13-14-43-38(26-30)45-29-21-27(22-31(25-29)53-4)40(49)44-15-16-48-17-19-57(52)20-18-48/h7-14,21-26H,15-20H2,1-6H3,(H,43,45)(H,44,49)(H2,46,47,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM381150 (3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1 Show InChI InChI=1S/C42H48N6O7S2/c1-42(2,3)28-23-35(39(54-5)37(24-28)56(6)51)47-41(50)46-34-11-12-36(33-10-8-7-9-32(33)34)55-30-13-14-43-38(26-30)45-29-21-27(22-31(25-29)53-4)40(49)44-15-16-48-17-19-57(52)20-18-48/h7-14,21-26H,15-20H2,1-6H3,(H,43,45)(H,44,49)(H2,46,47,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 1: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining ...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM381150 (3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1 Show InChI InChI=1S/C42H48N6O7S2/c1-42(2,3)28-23-35(39(54-5)37(24-28)56(6)51)47-41(50)46-34-11-12-36(33-10-8-7-9-32(33)34)55-30-13-14-43-38(26-30)45-29-21-27(22-31(25-29)53-4)40(49)44-15-16-48-17-19-57(52)20-18-48/h7-14,21-26H,15-20H2,1-6H3,(H,43,45)(H,44,49)(H2,46,47,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM381150 (3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCS(=O)CC1 Show InChI InChI=1S/C42H48N6O7S2/c1-42(2,3)28-23-35(39(54-5)37(24-28)56(6)51)47-41(50)46-34-11-12-36(33-10-8-7-9-32(33)34)55-30-13-14-43-38(26-30)45-29-21-27(22-31(25-29)53-4)40(49)44-15-16-48-17-19-57(52)20-18-48/h7-14,21-26H,15-20H2,1-6H3,(H,43,45)(H,44,49)(H2,46,47,50)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair