null

SMILES: COCCNC(=O)CN(C)CC(=O)NCCOCCOCCNC(=O)NCCOCCOCCOCCN1CCN(CC1)c1cccc(c1)-c1nc(NC(N)=N)nc2ccc(Cl)cc12

InChI Key: InChIKey=WGQLMPGAHQTGDI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 381685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/hydrogen exchanger 3 (Homo sapiens (Human))	BDBM381685 (US10272079, Compound 42) Show SMILES COCCNC(=O)CN(C)CC(=O)NCCOCCOCCNC(=O)NCCOCCOCCOCCN1CCN(CC1)c1cccc(c1)-c1nc(NC(N)=N)nc2ccc(Cl)cc12 Show InChI InChI=1S/C42H65ClN12O9/c1-53(30-37(56)46-8-17-59-2)31-38(57)47-9-18-60-22-23-61-19-10-48-42(58)49-11-20-62-24-26-64-27-25-63-21-16-54-12-14-55(15-13-54)34-5-3-4-32(28-34)39-35-29-33(43)6-7-36(35)50-41(51-39)52-40(44)45/h3-7,28-29H,8-27,30-31H2,1-2H3,(H,46,56)(H,47,57)(H2,48,49,58)(H4,44,45,50,51,52)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.31	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q2251MHH
					More data for this Ligand-Target Pair
Sodium/hydrogen exchanger 3 (Rattus norvegicus)	BDBM381685 (US10272079, Compound 42) Show SMILES COCCNC(=O)CN(C)CC(=O)NCCOCCOCCNC(=O)NCCOCCOCCOCCN1CCN(CC1)c1cccc(c1)-c1nc(NC(N)=N)nc2ccc(Cl)cc12 Show InChI InChI=1S/C42H65ClN12O9/c1-53(30-37(56)46-8-17-59-2)31-38(57)47-9-18-60-22-23-61-19-10-48-42(58)49-11-20-62-24-26-64-27-25-63-21-16-54-12-14-55(15-13-54)34-5-3-4-32(28-34)39-35-29-33(43)6-7-36(35)50-41(51-39)52-40(44)45/h3-7,28-29H,8-27,30-31H2,1-2H3,(H,46,56)(H,47,57)(H2,48,49,58)(H4,44,45,50,51,52)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q2251MHH
					More data for this Ligand-Target Pair