null

SMILES: N[C@@H]1CCCN(C1)[C@H]1Cc2c(cc(Cl)cc2Cl)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3Cl)N2CCC[C@@H](N)C2)cc1

InChI Key: InChIKey=AYMVQQDBIDBBFI-UADKWFTKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 381778   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/hydrogen exchanger 3 (Homo sapiens (Human))	BDBM381778 (US10272079, Compound 135) Show SMILES N[C@@H]1CCCN(C1)[C@H]1Cc2c(cc(Cl)cc2Cl)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3Cl)N2CCC[C@@H](N)C2)cc1 |r| Show InChI InChI=1S/C58H80Cl4N10O12S2/c59-39-31-49-47(51(61)33-39)35-53(71-21-3-5-41(63)37-71)55(49)83-43-7-11-45(12-8-43)85(75,76)69-19-25-81-29-27-79-23-17-67-57(73)65-15-1-2-16-66-58(74)68-18-24-80-28-30-82-26-20-70-86(77,78)46-13-9-44(10-14-46)84-56-50-32-40(60)34-52(62)48(50)36-54(56)72-22-4-6-42(64)38-72/h7-14,31-34,41-42,53-56,69-70H,1-6,15-30,35-38,63-64H2,(H2,65,67,73)(H2,66,68,74)/t41-,42-,53+,54+,55+,56+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.55	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q2251MHH
					More data for this Ligand-Target Pair
Sodium/hydrogen exchanger 3 (Rattus norvegicus)	BDBM381778 (US10272079, Compound 135) Show SMILES N[C@@H]1CCCN(C1)[C@H]1Cc2c(cc(Cl)cc2Cl)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3Cl)N2CCC[C@@H](N)C2)cc1 |r| Show InChI InChI=1S/C58H80Cl4N10O12S2/c59-39-31-49-47(51(61)33-39)35-53(71-21-3-5-41(63)37-71)55(49)83-43-7-11-45(12-8-43)85(75,76)69-19-25-81-29-27-79-23-17-67-57(73)65-15-1-2-16-66-58(74)68-18-24-80-28-30-82-26-20-70-86(77,78)46-13-9-44(10-14-46)84-56-50-32-40(60)34-52(62)48(50)36-54(56)72-22-4-6-42(64)38-72/h7-14,31-34,41-42,53-56,69-70H,1-6,15-30,35-38,63-64H2,(H2,65,67,73)(H2,66,68,74)/t41-,42-,53+,54+,55+,56+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.8	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q2251MHH
					More data for this Ligand-Target Pair