null

SMILES: O[C@@H]1CCN(C1)[C@H]1Cc2c(cc(Cl)cc2F)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3F)N2CC[C@@H](O)C2)cc1

InChI Key: InChIKey=VSLGVHBORZOXHE-CINCTQFYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 381808   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/hydrogen exchanger 3 (Homo sapiens (Human))	BDBM381808 (US10272079, Compound 165) Show SMILES O[C@@H]1CCN(C1)[C@H]1Cc2c(cc(Cl)cc2F)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3F)N2CC[C@@H](O)C2)cc1 |r| Show InChI InChI=1S/C56H74Cl2F2N8O14S2/c57-37-29-47-45(49(59)31-37)33-51(67-19-11-39(69)35-67)53(47)81-41-3-7-43(8-4-41)83(73,74)65-17-23-79-27-25-77-21-15-63-55(71)61-13-1-2-14-62-56(72)64-16-22-78-26-28-80-24-18-66-84(75,76)44-9-5-42(6-10-44)82-54-48-30-38(58)32-50(60)46(48)34-52(54)68-20-12-40(70)36-68/h3-10,29-32,39-40,51-54,65-66,69-70H,1-2,11-28,33-36H2,(H2,61,63,71)(H2,62,64,72)/t39-,40-,51+,52+,53+,54+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.31	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q2251MHH
					More data for this Ligand-Target Pair
Sodium/hydrogen exchanger 3 (Rattus norvegicus)	BDBM381808 (US10272079, Compound 165) Show SMILES O[C@@H]1CCN(C1)[C@H]1Cc2c(cc(Cl)cc2F)[C@@H]1Oc1ccc(cc1)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3F)N2CC[C@@H](O)C2)cc1 |r| Show InChI InChI=1S/C56H74Cl2F2N8O14S2/c57-37-29-47-45(49(59)31-37)33-51(67-19-11-39(69)35-67)53(47)81-41-3-7-43(8-4-41)83(73,74)65-17-23-79-27-25-77-21-15-63-55(71)61-13-1-2-14-62-56(72)64-16-22-78-26-28-80-24-18-66-84(75,76)44-9-5-42(6-10-44)82-54-48-30-38(58)32-50(60)46(48)34-52(54)68-20-12-40(70)36-68/h3-10,29-32,39-40,51-54,65-66,69-70H,1-2,11-28,33-36H2,(H2,61,63,71)(H2,62,64,72)/t39-,40-,51+,52+,53+,54+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q2251MHH
					More data for this Ligand-Target Pair