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BDBM382130 4-(4-((2-(6-amino-5-(trifluoromethyl)pyridin-3-yl)cyclohex-1-en-1-yl)methoxy)phenyl)butanoic Acid::US10273230, Compound of Example 8

SMILES: Nc1ncc(cc1C(F)(F)F)C1=C(COc2ccc(CCCC(O)=O)cc2)CCCC1

InChI Key: InChIKey=YGOBABBEPUEFBA-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 382130   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 120


(Homo sapiens (Human))		BDBM382130
PNG
(4-(4-((2-(6-amino-5-(trifluoromethyl)pyridin-3-yl)...)
Show SMILES Nc1ncc(cc1C(F)(F)F)C1=C(COc2ccc(CCCC(O)=O)cc2)CCCC1 |c:12|
Show InChI InChI=1S/C23H25F3N2O3/c24-23(25,26)20-12-17(13-28-22(20)27)19-6-2-1-5-16(19)14-31-18-10-8-15(9-11-18)4-3-7-21(29)30/h8-13H,1-7,14H2,(H2,27,28)(H,29,30)
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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.75E+3n/an/an/an/a



IRBM/Merck



Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120 receptor using β-galactosi...

Bioorg Med Chem Lett 18: 3456-61 (2008)


BindingDB Entry DOI: 10.7270/Q2154KBP
More data for this
Ligand-Target Pair