BDBM382270 US10273244, Example 139::US10584135, Example 139

SMILES: Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccncn1

InChI Key: InChIKey=PVENBHMDIHLYQL-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 382270   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM382270 (US10273244, Example 139 | US10584135, Example 139) Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccncn1 Show InChI InChI=1S/C22H26FN7S/c1-28-21(19-7-9-24-15-25-19)26-27-22(28)31-12-2-10-29-13-16-8-11-30(20(16)14-29)18-5-3-17(23)4-6-18/h3-7,9,15-16,20H,2,8,10-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INDIVIOR UK LIMITED US Patent					Assay Description [3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...				US Patent US10584135 (2020) BindingDB Entry DOI: 10.7270/Q29S1TFG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM382270 (US10273244, Example 139 | US10584135, Example 139) Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccncn1 Show InChI InChI=1S/C22H26FN7S/c1-28-21(19-7-9-24-15-25-19)26-27-22(28)31-12-2-10-29-13-16-8-11-30(20(16)14-29)18-5-3-17(23)4-6-18/h3-7,9,15-16,20H,2,8,10-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
IRBM/Merck					Assay Description 3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...				Bioorg Med Chem Lett 18: 3456-61 (2008) BindingDB Entry DOI: 10.7270/Q2RN3B5H
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM382270 (US10273244, Example 139 | US10584135, Example 139) Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccncn1 Show InChI InChI=1S/C22H26FN7S/c1-28-21(19-7-9-24-15-25-19)26-27-22(28)31-12-2-10-29-13-16-8-11-30(20(16)14-29)18-5-3-17(23)4-6-18/h3-7,9,15-16,20H,2,8,10-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	38.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
INDIVIOR UK LIMITED US Patent					Assay Description CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...				US Patent US10584135 (2020) BindingDB Entry DOI: 10.7270/Q29S1TFG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM382270 (US10273244, Example 139 | US10584135, Example 139) Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccncn1 Show InChI InChI=1S/C22H26FN7S/c1-28-21(19-7-9-24-15-25-19)26-27-22(28)31-12-2-10-29-13-16-8-11-30(20(16)14-29)18-5-3-17(23)4-6-18/h3-7,9,15-16,20H,2,8,10-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	38.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
IRBM/Merck					Assay Description Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...				Bioorg Med Chem Lett 18: 3456-61 (2008) BindingDB Entry DOI: 10.7270/Q2RN3B5H
					More data for this Ligand-Target Pair