null

SMILES: CNc1nc(Nc2cnn(CC34CC(C3)(C4)C#N)c2C)ncc1C(F)(F)F

InChI Key: InChIKey=UCLRBNKFQCMHFM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384297   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384297 (US10590114, No. 7 | US11111235, No. 7 | US9932325,...) Show SMILES CNc1nc(Nc2cnn(CC34CC(C3)(C4)C#N)c2C)ncc1C(F)(F)F Show InChI InChI=1S/C17H18F3N7/c1-10-12(4-24-27(10)9-16-5-15(6-16,7-16)8-21)25-14-23-3-11(17(18,19)20)13(22-2)26-14/h3-4H,5-7,9H2,1-2H3,(H2,22,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				Bioorg Med Chem Lett 18: 2567-73 (2008) BindingDB Entry DOI: 10.7270/Q29G5Q4M
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384297 (US10590114, No. 7 | US11111235, No. 7 | US9932325,...) Show SMILES CNc1nc(Nc2cnn(CC34CC(C3)(C4)C#N)c2C)ncc1C(F)(F)F Show InChI InChI=1S/C17H18F3N7/c1-10-12(4-24-27(10)9-16-5-15(6-16,7-16)8-21)25-14-23-3-11(17(18,19)20)13(22-2)26-14/h3-4H,5-7,9H2,1-2H3,(H2,22,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM384297 (US10590114, No. 7 | US11111235, No. 7 | US9932325,...) Show SMILES CNc1nc(Nc2cnn(CC34CC(C3)(C4)C#N)c2C)ncc1C(F)(F)F Show InChI InChI=1S/C17H18F3N7/c1-10-12(4-24-27(10)9-16-5-15(6-16,7-16)8-21)25-14-23-3-11(17(18,19)20)13(22-2)26-14/h3-4H,5-7,9H2,1-2H3,(H2,22,23,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapautics Inc. US Patent					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				US Patent US10590114 (2020)
					More data for this Ligand-Target Pair