BDBM385680 4-(5-{[3- (dimethylamino) propyl]amino}- [1,2,4]triazolo[1,5- a]pyrimidin-7- yl)benzonitrile::US10287286, Example 88

SMILES: CN(C)CCCNc1cc(-c2ccc(cc2)C#N)n2ncnc2n1

InChI Key: InChIKey=JUIXYUJHCFKWFY-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 385680   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Egl nine homolog 2 (Homo sapiens (Human))	BDBM385680 (4-(5-{[3- (dimethylamino) propyl]amino}- [1,2,4]tr...) Show SMILES CN(C)CCCNc1cc(-c2ccc(cc2)C#N)n2ncnc2n1 Show InChI InChI=1S/C17H19N7/c1-23(2)9-3-8-19-16-10-15(24-17(22-16)20-12-21-24)14-6-4-13(11-18)5-7-14/h4-7,10,12H,3,8-9H2,1-2H3,(H,19,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair