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BDBM385722 2-fluoro-4-(7-{[(3- methyloxetan-3- yl)methyl]amino}- [1,2,4]triazolo[1,5- a]pyridin-5- yl)benzonitrile::US10287286, Example 127

SMILES: CC1(CNc2cc(-c3ccc(C#N)c(F)c3)n3ncnc3c2)COC1

InChI Key: InChIKey=RXMYAFFQPTUGQU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 385722   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Egl nine homolog 2


(Homo sapiens (Human))		BDBM385722
PNG
(2-fluoro-4-(7-{[(3- methyloxetan-3- yl)methyl]amin...)
Show SMILES CC1(CNc2cc(-c3ccc(C#N)c(F)c3)n3ncnc3c2)COC1
Show InChI InChI=1S/C18H16FN5O/c1-18(9-25-10-18)8-21-14-5-16(24-17(6-14)22-11-23-24)12-2-3-13(7-20)15(19)4-12/h2-6,11,21H,8-10H2,1H3
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US Patent
n/an/a 47n/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...

Bioorg Med Chem 16: 7424-8 (2008)


BindingDB Entry DOI: 10.7270/Q2QJ7KMD
More data for this
Ligand-Target Pair