null

SMILES: NCC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=GEKRHWYIFQTBAI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385993   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proline-rich AKT1 substrate 1 (Homo sapiens (Human))	BDBM385993 (2-(1-(2,3-dihydro-1H-pyrrolo[2,3]pyrimidin-4-yl)pi...) Show SMILES NCC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H23F3N6/c20-19(21,22)14-3-1-13(2-4-14)16(11-23)27-7-9-28(10-8-27)18-15-5-6-24-17(15)25-12-26-18/h1-4,12,16H,5-11,23H2,(H,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase beta-1 [T412E] (Homo sapiens (Human))	BDBM385993 (2-(1-(2,3-dihydro-1H-pyrrolo[2,3]pyrimidin-4-yl)pi...) Show SMILES NCC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H23F3N6/c20-19(21,22)14-3-1-13(2-4-14)16(11-23)27-7-9-28(10-8-27)18-15-5-6-24-17(15)25-12-26-18/h1-4,12,16H,5-11,23H2,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B
					More data for this Ligand-Target Pair