null

SMILES: CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=NJXGWQYQVIYERY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385999   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proline-rich AKT1 substrate 1 (Homo sapiens (Human))	BDBM385999 (US10287300, Compound A6 | [2-[4-(6,7-Dihydro-5H-py...) Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H27F3N6/c1-28(2)13-18(15-3-5-16(6-4-15)21(22,23)24)29-9-11-30(12-10-29)20-17-7-8-25-19(17)26-14-27-20/h3-6,14,18H,7-13H2,1-2H3,(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase beta-1 [T412E] (Homo sapiens (Human))	BDBM385999 (US10287300, Compound A6 | [2-[4-(6,7-Dihydro-5H-py...) Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H27F3N6/c1-28(2)13-18(15-3-5-16(6-4-15)21(22,23)24)29-9-11-30(12-10-29)20-17-7-8-25-19(17)26-14-27-20/h3-6,14,18H,7-13H2,1-2H3,(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B
					More data for this Ligand-Target Pair