null
SMILES: CN(C)CC(N1CCN(CC1)c1ncnc2NCCCc12)c1ccc(Cl)cc1
InChI Key: InChIKey=CIKHQGUERLEIEN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proline-rich AKT1 substrate 1 (Homo sapiens (Human)) | BDBM386001 (US10287300, Compound A8 | {2-(4-Chlorophenyl)-2-[4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1 [T412E] (Homo sapiens (Human)) | BDBM386001 (US10287300, Compound A8 | {2-(4-Chlorophenyl)-2-[4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair |