BDBM386015 US10287300, Compound A21::[2-[4-(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-2-(3-fluoro-4-trifluoromethyl-phenyl)-ethyl]-dimethylamine
SMILES: CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(c(F)c1)C(F)(F)F
InChI Key: InChIKey=BRCQOPRRHNTMQT-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proline-rich AKT1 substrate 1 (Homo sapiens (Human)) | BDBM386015 (US10287300, Compound A21 | [2-[4-(6,7-Dihydro-5H-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P70S6K (T412E) (Homo sapiens (Human)) | BDBM386015 (US10287300, Compound A21 | [2-[4-(6,7-Dihydro-5H-p...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair |