BDBM386020 4-{4-[2-dimethylamino-1-(4-chloro-phenyl)-ethyl]-piperazin-1-yl}-7,8-dihydro-5H-pteridin-6-one::US10287300, Compound A26
SMILES: CN(C)CC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccc(Cl)cc1
InChI Key: InChIKey=GGSORKMSCJCDLN-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proline-rich AKT1 substrate 1 (Homo sapiens (Human)) | BDBM386020![]() (4-{4-[2-dimethylamino-1-(4-chloro-phenyl)-ethyl]-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1 [T412E] (Homo sapiens (Human)) | BDBM386020![]() (4-{4-[2-dimethylamino-1-(4-chloro-phenyl)-ethyl]-p...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair |