null

SMILES: CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1

InChI Key: InChIKey=GWXIWAAZEKCXMJ-RDGPPVDQSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 386065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386065 (N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:16.20,13.13,10.11,5.4,(6.99,-1.33,;5.9,-.24,;5.5,1.25,;6.99,.85,;4.41,-.64,;4.01,-2.12,;5.1,-3.21,;4.7,-4.7,;3.21,-5.1,;2.12,-4.01,;2.52,-2.52,;1.43,-1.43,;-.05,-1.83,;-1.14,-.74,;-2.63,-1.14,;-3.72,-.05,;-3.32,1.43,;-1.83,1.83,;-.74,.74,;-4.41,2.52,;-4.01,4.01,;-5.1,5.1,;-6.59,4.7,;-6.99,3.21,;-5.9,2.12,)| Show InChI InChI=1S/C19H30N2O3S/c1-25(22,23)21-18-8-5-13-20-19(18)14-24-17-11-9-16(10-12-17)15-6-3-2-4-7-15/h2-4,6-7,16-21H,5,8-14H2,1H3/t16-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				J Med Chem 50: 2213-24 (2007) BindingDB Entry DOI: 10.7270/Q2Z321Z2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386065 (N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:16.20,13.13,10.11,5.4,(6.99,-1.33,;5.9,-.24,;5.5,1.25,;6.99,.85,;4.41,-.64,;4.01,-2.12,;5.1,-3.21,;4.7,-4.7,;3.21,-5.1,;2.12,-4.01,;2.52,-2.52,;1.43,-1.43,;-.05,-1.83,;-1.14,-.74,;-2.63,-1.14,;-3.72,-.05,;-3.32,1.43,;-1.83,1.83,;-.74,.74,;-4.41,2.52,;-4.01,4.01,;-5.1,5.1,;-6.59,4.7,;-6.99,3.21,;-5.9,2.12,)| Show InChI InChI=1S/C19H30N2O3S/c1-25(22,23)21-18-8-5-13-20-19(18)14-24-17-11-9-16(10-12-17)15-6-3-2-4-7-15/h2-4,6-7,16-21H,5,8-14H2,1H3/t16-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				J Med Chem 50: 2213-24 (2007) BindingDB Entry DOI: 10.7270/Q2Z321Z2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386065 (N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:16.20,13.13,10.11,5.4,(6.99,-1.33,;5.9,-.24,;5.5,1.25,;6.99,.85,;4.41,-.64,;4.01,-2.12,;5.1,-3.21,;4.7,-4.7,;3.21,-5.1,;2.12,-4.01,;2.52,-2.52,;1.43,-1.43,;-.05,-1.83,;-1.14,-.74,;-2.63,-1.14,;-3.72,-.05,;-3.32,1.43,;-1.83,1.83,;-.74,.74,;-4.41,2.52,;-4.01,4.01,;-5.1,5.1,;-6.59,4.7,;-6.99,3.21,;-5.9,2.12,)| Show InChI InChI=1S/C19H30N2O3S/c1-25(22,23)21-18-8-5-13-20-19(18)14-24-17-11-9-16(10-12-17)15-6-3-2-4-7-15/h2-4,6-7,16-21H,5,8-14H2,1H3/t16-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386065 (N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:16.20,13.13,10.11,5.4,(6.99,-1.33,;5.9,-.24,;5.5,1.25,;6.99,.85,;4.41,-.64,;4.01,-2.12,;5.1,-3.21,;4.7,-4.7,;3.21,-5.1,;2.12,-4.01,;2.52,-2.52,;1.43,-1.43,;-.05,-1.83,;-1.14,-.74,;-2.63,-1.14,;-3.72,-.05,;-3.32,1.43,;-1.83,1.83,;-.74,.74,;-4.41,2.52,;-4.01,4.01,;-5.1,5.1,;-6.59,4.7,;-6.99,3.21,;-5.9,2.12,)| Show InChI InChI=1S/C19H30N2O3S/c1-25(22,23)21-18-8-5-13-20-19(18)14-24-17-11-9-16(10-12-17)15-6-3-2-4-7-15/h2-4,6-7,16-21H,5,8-14H2,1H3/t16-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				US Patent US10508083 (2019) BindingDB Entry DOI: 10.7270/Q29S1TD1
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386065 (N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:16.20,13.13,10.11,5.4,(6.99,-1.33,;5.9,-.24,;5.5,1.25,;6.99,.85,;4.41,-.64,;4.01,-2.12,;5.1,-3.21,;4.7,-4.7,;3.21,-5.1,;2.12,-4.01,;2.52,-2.52,;1.43,-1.43,;-.05,-1.83,;-1.14,-.74,;-2.63,-1.14,;-3.72,-.05,;-3.32,1.43,;-1.83,1.83,;-.74,.74,;-4.41,2.52,;-4.01,4.01,;-5.1,5.1,;-6.59,4.7,;-6.99,3.21,;-5.9,2.12,)| Show InChI InChI=1S/C19H30N2O3S/c1-25(22,23)21-18-8-5-13-20-19(18)14-24-17-11-9-16(10-12-17)15-6-3-2-4-7-15/h2-4,6-7,16-21H,5,8-14H2,1H3/t16-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386065 (N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:16.20,13.13,10.11,5.4,(6.99,-1.33,;5.9,-.24,;5.5,1.25,;6.99,.85,;4.41,-.64,;4.01,-2.12,;5.1,-3.21,;4.7,-4.7,;3.21,-5.1,;2.12,-4.01,;2.52,-2.52,;1.43,-1.43,;-.05,-1.83,;-1.14,-.74,;-2.63,-1.14,;-3.72,-.05,;-3.32,1.43,;-1.83,1.83,;-.74,.74,;-4.41,2.52,;-4.01,4.01,;-5.1,5.1,;-6.59,4.7,;-6.99,3.21,;-5.9,2.12,)| Show InChI InChI=1S/C19H30N2O3S/c1-25(22,23)21-18-8-5-13-20-19(18)14-24-17-11-9-16(10-12-17)15-6-3-2-4-7-15/h2-4,6-7,16-21H,5,8-14H2,1H3/t16-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				US Patent US10508083 (2019) BindingDB Entry DOI: 10.7270/Q29S1TD1
					More data for this Ligand-Target Pair