null

SMILES: CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1

InChI Key: InChIKey=DATADCLNOZHNAB-PZGXJPJSSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386068   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386068 (N-((2R,3S)-2-(((cis-4-(3,5- difluorophenyl)cyclohe...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1 |r,wU:16.20,13.13,10.11,5.4,(7.34,-1.16,;6,-.39,;5.23,.95,;6.77,.95,;4.67,-1.16,;4.67,-2.7,;6,-3.47,;6,-5.01,;4.67,-5.78,;3.33,-5.01,;3.33,-3.47,;2,-2.7,;2,-1.16,;.67,-.39,;-.67,-1.16,;-2,-.39,;-2,1.15,;-.67,1.92,;.67,1.15,;-3.33,1.92,;-4.67,1.15,;-6,1.92,;-7.34,1.15,;-6,3.46,;-4.67,4.24,;-4.67,5.78,;-3.33,3.46,)| Show InChI InChI=1S/C19H28F2N2O3S/c1-27(24,25)23-18-3-2-8-22-19(18)12-26-17-6-4-13(5-7-17)14-9-15(20)11-16(21)10-14/h9-11,13,17-19,22-23H,2-8,12H2,1H3/t13-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				J Med Chem 50: 2213-24 (2007) BindingDB Entry DOI: 10.7270/Q2Z321Z2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386068 (N-((2R,3S)-2-(((cis-4-(3,5- difluorophenyl)cyclohe...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1 |r,wU:16.20,13.13,10.11,5.4,(7.34,-1.16,;6,-.39,;5.23,.95,;6.77,.95,;4.67,-1.16,;4.67,-2.7,;6,-3.47,;6,-5.01,;4.67,-5.78,;3.33,-5.01,;3.33,-3.47,;2,-2.7,;2,-1.16,;.67,-.39,;-.67,-1.16,;-2,-.39,;-2,1.15,;-.67,1.92,;.67,1.15,;-3.33,1.92,;-4.67,1.15,;-6,1.92,;-7.34,1.15,;-6,3.46,;-4.67,4.24,;-4.67,5.78,;-3.33,3.46,)| Show InChI InChI=1S/C19H28F2N2O3S/c1-27(24,25)23-18-3-2-8-22-19(18)12-26-17-6-4-13(5-7-17)14-9-15(20)11-16(21)10-14/h9-11,13,17-19,22-23H,2-8,12H2,1H3/t13-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386068 (N-((2R,3S)-2-(((cis-4-(3,5- difluorophenyl)cyclohe...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1 |r,wU:16.20,13.13,10.11,5.4,(7.34,-1.16,;6,-.39,;5.23,.95,;6.77,.95,;4.67,-1.16,;4.67,-2.7,;6,-3.47,;6,-5.01,;4.67,-5.78,;3.33,-5.01,;3.33,-3.47,;2,-2.7,;2,-1.16,;.67,-.39,;-.67,-1.16,;-2,-.39,;-2,1.15,;-.67,1.92,;.67,1.15,;-3.33,1.92,;-4.67,1.15,;-6,1.92,;-7.34,1.15,;-6,3.46,;-4.67,4.24,;-4.67,5.78,;-3.33,3.46,)| Show InChI InChI=1S/C19H28F2N2O3S/c1-27(24,25)23-18-3-2-8-22-19(18)12-26-17-6-4-13(5-7-17)14-9-15(20)11-16(21)10-14/h9-11,13,17-19,22-23H,2-8,12H2,1H3/t13-,17+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				US Patent US10508083 (2019) BindingDB Entry DOI: 10.7270/Q29S1TD1
					More data for this Ligand-Target Pair