null

SMILES: CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1

InChI Key: InChIKey=UXDYZLFWHWIPME-ZFCZOSEKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386069   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386069 (N-((2R,3S)-1-acetyl-2-(((cis-4- (3,5- difluorophen...) Show SMILES CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1 |r,wU:19.23,16.16,13.14,7.7,(.67,-4.23,;2,-5,;2,-6.54,;3.33,-4.24,;4.67,-5.01,;6,-4.24,;6,-2.7,;4.67,-1.93,;4.67,-.39,;6,.38,;7.34,-.39,;5.23,1.72,;6.77,1.72,;3.33,-2.7,;2,-1.93,;2,-.39,;.67,.38,;-.67,-.39,;-2,.38,;-2,1.92,;-.67,2.69,;.67,1.92,;-3.33,2.69,;-4.67,1.92,;-6,2.69,;-7.34,1.92,;-6,4.23,;-4.67,5,;-4.67,6.54,;-3.33,4.23,)| Show InChI InChI=1S/C21H30F2N2O4S/c1-14(26)25-9-3-4-20(24-30(2,27)28)21(25)13-29-19-7-5-15(6-8-19)16-10-17(22)12-18(23)11-16/h10-12,15,19-21,24H,3-9,13H2,1-2H3/t15-,19+,20-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.60	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				J Med Chem 50: 2213-24 (2007) BindingDB Entry DOI: 10.7270/Q2Z321Z2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386069 (N-((2R,3S)-1-acetyl-2-(((cis-4- (3,5- difluorophen...) Show SMILES CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1 |r,wU:19.23,16.16,13.14,7.7,(.67,-4.23,;2,-5,;2,-6.54,;3.33,-4.24,;4.67,-5.01,;6,-4.24,;6,-2.7,;4.67,-1.93,;4.67,-.39,;6,.38,;7.34,-.39,;5.23,1.72,;6.77,1.72,;3.33,-2.7,;2,-1.93,;2,-.39,;.67,.38,;-.67,-.39,;-2,.38,;-2,1.92,;-.67,2.69,;.67,1.92,;-3.33,2.69,;-4.67,1.92,;-6,2.69,;-7.34,1.92,;-6,4.23,;-4.67,5,;-4.67,6.54,;-3.33,4.23,)| Show InChI InChI=1S/C21H30F2N2O4S/c1-14(26)25-9-3-4-20(24-30(2,27)28)21(25)13-29-19-7-5-15(6-8-19)16-10-17(22)12-18(23)11-16/h10-12,15,19-21,24H,3-9,13H2,1-2H3/t15-,19+,20-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	5.60	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386069 (N-((2R,3S)-1-acetyl-2-(((cis-4- (3,5- difluorophen...) Show SMILES CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)cc(F)c1 |r,wU:19.23,16.16,13.14,7.7,(.67,-4.23,;2,-5,;2,-6.54,;3.33,-4.24,;4.67,-5.01,;6,-4.24,;6,-2.7,;4.67,-1.93,;4.67,-.39,;6,.38,;7.34,-.39,;5.23,1.72,;6.77,1.72,;3.33,-2.7,;2,-1.93,;2,-.39,;.67,.38,;-.67,-.39,;-2,.38,;-2,1.92,;-.67,2.69,;.67,1.92,;-3.33,2.69,;-4.67,1.92,;-6,2.69,;-7.34,1.92,;-6,4.23,;-4.67,5,;-4.67,6.54,;-3.33,4.23,)| Show InChI InChI=1S/C21H30F2N2O4S/c1-14(26)25-9-3-4-20(24-30(2,27)28)21(25)13-29-19-7-5-15(6-8-19)16-10-17(22)12-18(23)11-16/h10-12,15,19-21,24H,3-9,13H2,1-2H3/t15-,19+,20-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.60	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				US Patent US10508083 (2019) BindingDB Entry DOI: 10.7270/Q29S1TD1
					More data for this Ligand-Target Pair