null

SMILES: CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1c(F)ccc(F)c1F

InChI Key: InChIKey=REOONBLHEVHLQF-RMHZUWNSSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386079   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386079 (N-((2R,3S)-2-(((cis-4-(2,3,6- trifluorophenyl)cycl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1c(F)ccc(F)c1F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.16,;5.33,-.39,;4.56,.95,;6.1,.95,;4,-1.16,;4,-2.7,;5.33,-3.47,;5.33,-5.01,;4,-5.78,;2.67,-5.01,;2.67,-3.47,;1.33,-2.7,;1.33,-1.16,;,-.39,;-1.33,-1.16,;-2.67,-.39,;-2.67,1.15,;-1.33,1.92,;,1.15,;-4,1.92,;-5.33,1.15,;-5.33,-.38,;-6.67,1.92,;-6.67,3.46,;-5.33,4.24,;-5.33,5.78,;-4,3.46,;-2.67,4.23,)| Show InChI InChI=1S/C19H27F3N2O3S/c1-28(25,26)24-16-3-2-10-23-17(16)11-27-13-6-4-12(5-7-13)18-14(20)8-9-15(21)19(18)22/h8-9,12-13,16-17,23-24H,2-7,10-11H2,1H3/t12-,13+,16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				J Med Chem 50: 2213-24 (2007) BindingDB Entry DOI: 10.7270/Q2Z321Z2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386079 (N-((2R,3S)-2-(((cis-4-(2,3,6- trifluorophenyl)cycl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1c(F)ccc(F)c1F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.16,;5.33,-.39,;4.56,.95,;6.1,.95,;4,-1.16,;4,-2.7,;5.33,-3.47,;5.33,-5.01,;4,-5.78,;2.67,-5.01,;2.67,-3.47,;1.33,-2.7,;1.33,-1.16,;,-.39,;-1.33,-1.16,;-2.67,-.39,;-2.67,1.15,;-1.33,1.92,;,1.15,;-4,1.92,;-5.33,1.15,;-5.33,-.38,;-6.67,1.92,;-6.67,3.46,;-5.33,4.24,;-5.33,5.78,;-4,3.46,;-2.67,4.23,)| Show InChI InChI=1S/C19H27F3N2O3S/c1-28(25,26)24-16-3-2-10-23-17(16)11-27-13-6-4-12(5-7-13)18-14(20)8-9-15(21)19(18)22/h8-9,12-13,16-17,23-24H,2-7,10-11H2,1H3/t12-,13+,16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386079 (N-((2R,3S)-2-(((cis-4-(2,3,6- trifluorophenyl)cycl...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1c(F)ccc(F)c1F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.16,;5.33,-.39,;4.56,.95,;6.1,.95,;4,-1.16,;4,-2.7,;5.33,-3.47,;5.33,-5.01,;4,-5.78,;2.67,-5.01,;2.67,-3.47,;1.33,-2.7,;1.33,-1.16,;,-.39,;-1.33,-1.16,;-2.67,-.39,;-2.67,1.15,;-1.33,1.92,;,1.15,;-4,1.92,;-5.33,1.15,;-5.33,-.38,;-6.67,1.92,;-6.67,3.46,;-5.33,4.24,;-5.33,5.78,;-4,3.46,;-2.67,4.23,)| Show InChI InChI=1S/C19H27F3N2O3S/c1-28(25,26)24-16-3-2-10-23-17(16)11-27-13-6-4-12(5-7-13)18-14(20)8-9-15(21)19(18)22/h8-9,12-13,16-17,23-24H,2-7,10-11H2,1H3/t12-,13+,16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				US Patent US10508083 (2019) BindingDB Entry DOI: 10.7270/Q29S1TD1
					More data for this Ligand-Target Pair