null

SMILES: CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1C(F)(F)F

InChI Key: InChIKey=KSRKXJHLVAZXQW-QXGSTGNESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386081   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386081 (N-((2R,3S)-2-(((cis-4-(2- (trifluoromethyl)phenyl)...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1C(F)(F)F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.15,;5.33,-.38,;4.56,.95,;6.1,.95,;4,-1.15,;4,-2.69,;5.33,-3.47,;5.33,-5,;4,-5.78,;2.67,-5,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.15,;-1.33,1.93,;,1.15,;-4,1.93,;-5.33,1.15,;-6.67,1.93,;-6.67,3.47,;-5.33,4.24,;-4,3.47,;-2.67,4.23,;-1.33,3.47,;-2.67,5.78,;-1.33,5,)| Show InChI InChI=1S/C20H29F3N2O3S/c1-29(26,27)25-18-7-4-12-24-19(18)13-28-15-10-8-14(9-11-15)16-5-2-3-6-17(16)20(21,22)23/h2-3,5-6,14-15,18-19,24-25H,4,7-13H2,1H3/t14-,15+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				J Med Chem 50: 2213-24 (2007) BindingDB Entry DOI: 10.7270/Q2Z321Z2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386081 (N-((2R,3S)-2-(((cis-4-(2- (trifluoromethyl)phenyl)...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1C(F)(F)F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.15,;5.33,-.38,;4.56,.95,;6.1,.95,;4,-1.15,;4,-2.69,;5.33,-3.47,;5.33,-5,;4,-5.78,;2.67,-5,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.15,;-1.33,1.93,;,1.15,;-4,1.93,;-5.33,1.15,;-6.67,1.93,;-6.67,3.47,;-5.33,4.24,;-4,3.47,;-2.67,4.23,;-1.33,3.47,;-2.67,5.78,;-1.33,5,)| Show InChI InChI=1S/C20H29F3N2O3S/c1-29(26,27)25-18-7-4-12-24-19(18)13-28-15-10-8-14(9-11-15)16-5-2-3-6-17(16)20(21,22)23/h2-3,5-6,14-15,18-19,24-25H,4,7-13H2,1H3/t14-,15+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CZ3BCW
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386081 (N-((2R,3S)-2-(((cis-4-(2- (trifluoromethyl)phenyl)...) Show SMILES CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1C(F)(F)F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.15,;5.33,-.38,;4.56,.95,;6.1,.95,;4,-1.15,;4,-2.69,;5.33,-3.47,;5.33,-5,;4,-5.78,;2.67,-5,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.15,;-1.33,1.93,;,1.15,;-4,1.93,;-5.33,1.15,;-6.67,1.93,;-6.67,3.47,;-5.33,4.24,;-4,3.47,;-2.67,4.23,;-1.33,3.47,;-2.67,5.78,;-1.33,5,)| Show InChI InChI=1S/C20H29F3N2O3S/c1-29(26,27)25-18-7-4-12-24-19(18)13-28-15-10-8-14(9-11-15)16-5-2-3-6-17(16)20(21,22)23/h2-3,5-6,14-15,18-19,24-25H,4,7-13H2,1H3/t14-,15+,18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				US Patent US10508083 (2019) BindingDB Entry DOI: 10.7270/Q29S1TD1
					More data for this Ligand-Target Pair