BDBM386103 US10287305, Example 43::US10508083, Example 43::US11292766, Example 43::phenyl cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-3- ((methylsulfonyl)amino)piperidine-1- carboxylate

SMILES: CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)Oc1ccccc1)NS(C)(=O)=O

InChI Key: InChIKey=HMWZHSIIIYBKOM-MXNKGDRCSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386103   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386103 (US10287305, Example 43 | US10508083, Example 43 | ...) Show SMILES CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)Oc1ccccc1)NS(C)(=O)=O |r,wU:3.2,6.9,11.11,12.28,(-6,3.47,;-4.67,4.23,;-4.67,5.78,;-3.33,3.47,;-3.33,1.93,;-2,1.15,;-.67,1.93,;-.67,3.47,;-2,4.23,;.67,1.15,;.67,-.38,;2,-1.15,;3.33,-.38,;4.67,-1.15,;4.67,-2.69,;3.33,-3.47,;2,-2.69,;.67,-3.47,;.67,-5,;-.67,-2.69,;-2,-3.47,;-3.33,-2.69,;-4.67,-3.47,;-4.67,-5,;-3.33,-5.78,;-2,-5,;3.33,1.15,;4.67,1.93,;6,1.15,;3.9,3.26,;5.44,3.26,)| Show InChI InChI=1S/C23H36N2O5S/c1-17(2)18-11-13-19(14-12-18)29-16-22-21(24-31(3,27)28)10-7-15-25(22)23(26)30-20-8-5-4-6-9-20/h4-6,8-9,17-19,21-22,24H,7,10-16H2,1-3H3/t18-,19+,21-,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				J Med Chem 50: 2213-24 (2007) BindingDB Entry DOI: 10.7270/Q2Z321Z2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386103 (US10287305, Example 43 | US10508083, Example 43 | ...) Show SMILES CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)Oc1ccccc1)NS(C)(=O)=O |r,wU:3.2,6.9,11.11,12.28,(-6,3.47,;-4.67,4.23,;-4.67,5.78,;-3.33,3.47,;-3.33,1.93,;-2,1.15,;-.67,1.93,;-.67,3.47,;-2,4.23,;.67,1.15,;.67,-.38,;2,-1.15,;3.33,-.38,;4.67,-1.15,;4.67,-2.69,;3.33,-3.47,;2,-2.69,;.67,-3.47,;.67,-5,;-.67,-2.69,;-2,-3.47,;-3.33,-2.69,;-4.67,-3.47,;-4.67,-5,;-3.33,-5.78,;-2,-5,;3.33,1.15,;4.67,1.93,;6,1.15,;3.9,3.26,;5.44,3.26,)| Show InChI InChI=1S/C23H36N2O5S/c1-17(2)18-11-13-19(14-12-18)29-16-22-21(24-31(3,27)28)10-7-15-25(22)23(26)30-20-8-5-4-6-9-20/h4-6,8-9,17-19,21-22,24H,7,10-16H2,1-3H3/t18-,19+,21-,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM386103 (US10287305, Example 43 | US10508083, Example 43 | ...) Show SMILES CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)Oc1ccccc1)NS(C)(=O)=O |r,wU:3.2,6.9,11.11,12.28,(-6,3.47,;-4.67,4.23,;-4.67,5.78,;-3.33,3.47,;-3.33,1.93,;-2,1.15,;-.67,1.93,;-.67,3.47,;-2,4.23,;.67,1.15,;.67,-.38,;2,-1.15,;3.33,-.38,;4.67,-1.15,;4.67,-2.69,;3.33,-3.47,;2,-2.69,;.67,-3.47,;.67,-5,;-.67,-2.69,;-2,-3.47,;-3.33,-2.69,;-4.67,-3.47,;-4.67,-5,;-3.33,-5.78,;-2,-5,;3.33,1.15,;4.67,1.93,;6,1.15,;3.9,3.26,;5.44,3.26,)| Show InChI InChI=1S/C23H36N2O5S/c1-17(2)18-11-13-19(14-12-18)29-16-22-21(24-31(3,27)28)10-7-15-25(22)23(26)30-20-8-5-4-6-9-20/h4-6,8-9,17-19,21-22,24H,7,10-16H2,1-3H3/t18-,19+,21-,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...				US Patent US10508083 (2019) BindingDB Entry DOI: 10.7270/Q29S1TD1
					More data for this Ligand-Target Pair