BDBM387185 1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[5.5]undecan-9-yl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol::US9938257, Example 37

SMILES: CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1

InChI Key: InChIKey=XVAFGIDSNSLOJM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM387185 (1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...) Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1 Show InChI InChI=1S/C22H34ClN7O3S/c1-21(2,31)15-29-14-17(12-25-29)27-20-24-13-18(23)19(28-20)26-16-4-6-22(7-5-16)8-10-30(11-9-22)34(3,32)33/h12-14,16,31H,4-11,15H2,1-3H3,(H2,24,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM387185 (1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...) Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1 Show InChI InChI=1S/C22H34ClN7O3S/c1-21(2,31)15-29-14-17(12-25-29)27-20-24-13-18(23)19(28-20)26-16-4-6-22(7-5-16)8-10-30(11-9-22)34(3,32)33/h12-14,16,31H,4-11,15H2,1-3H3,(H2,24,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM387185 (1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...) Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1 Show InChI InChI=1S/C22H34ClN7O3S/c1-21(2,31)15-29-14-17(12-25-29)27-20-24-13-18(23)19(28-20)26-16-4-6-22(7-5-16)8-10-30(11-9-22)34(3,32)33/h12-14,16,31H,4-11,15H2,1-3H3,(H2,24,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair