BDBM387331 6-chloro-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]quinolin-4-amine::US10292985, Example 15

SMILES: Cc1cccc(n1)-c1nc(Nc2ccnc3ccc(Cl)cc23)c2cccn2n1

InChI Key: InChIKey=AJRHVKPLEGOWCQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387331   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type II (Homo sapiens (Human))	BDBM387331 (6-chloro-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f]...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccnc3ccc(Cl)cc23)c2cccn2n1 Show InChI InChI=1S/C21H15ClN6/c1-13-4-2-5-18(24-13)20-26-21(19-6-3-11-28(19)27-20)25-17-9-10-23-16-8-7-14(22)12-15(16)17/h2-12H,1H3,(H,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California									J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387331 (6-chloro-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f]...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccnc3ccc(Cl)cc23)c2cccn2n1 Show InChI InChI=1S/C21H15ClN6/c1-13-4-2-5-18(24-13)20-26-21(19-6-3-11-28(19)27-20)25-17-9-10-23-16-8-7-14(22)12-15(16)17/h2-12H,1H3,(H,23,25,26,27)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair