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SMILES: CNc1cc2n(CCN(CCOC)C3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl

InChI Key: InChIKey=BZVKGXHIOHNRME-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387926   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM387926 (1-(2-((1-acryloylazetidin-3-yl)(2-methoxyethyl)ami...) Show SMILES CNc1cc2n(CCN(CCOC)C3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-4,-5.71,;-2.67,-6.48,;-1.33,-5.71,;-1.33,-4.17,;,-3.4,;,-1.86,;-1.33,-1.09,;-2.67,-1.86,;-4,-1.09,;-5.33,-1.86,;-6.67,-1.09,;-8,-1.86,;-9.34,-1.09,;-4,.45,;-5.09,1.54,;-4,2.63,;-2.91,1.54,;-4,4.17,;-2.67,4.94,;-5.33,4.94,;-5.33,6.48,;1.33,-1.09,;1.33,.45,;2.67,-1.86,;2.67,-3.4,;1.33,-4.17,;1.33,-5.71,;,-6.48,;4,-1.09,;4,.45,;2.67,1.22,;5.33,1.22,;5.33,2.76,;6.67,3.53,;6.67,.45,;6.67,-1.09,;8,-1.86,;9.34,-1.09,;5.33,-1.86,;5.33,-3.4,)| Show InChI InChI=1S/C28H33Cl2N5O5/c1-6-24(36)34-15-18(16-34)33(9-10-38-3)7-8-35-20-12-23(31-2)32-14-17(20)11-19(28(35)37)25-26(29)21(39-4)13-22(40-5)27(25)30/h6,11-14,18H,1,7-10,15-16H2,2-5H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM387926 (1-(2-((1-acryloylazetidin-3-yl)(2-methoxyethyl)ami...) Show SMILES CNc1cc2n(CCN(CCOC)C3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-4,-5.71,;-2.67,-6.48,;-1.33,-5.71,;-1.33,-4.17,;,-3.4,;,-1.86,;-1.33,-1.09,;-2.67,-1.86,;-4,-1.09,;-5.33,-1.86,;-6.67,-1.09,;-8,-1.86,;-9.34,-1.09,;-4,.45,;-5.09,1.54,;-4,2.63,;-2.91,1.54,;-4,4.17,;-2.67,4.94,;-5.33,4.94,;-5.33,6.48,;1.33,-1.09,;1.33,.45,;2.67,-1.86,;2.67,-3.4,;1.33,-4.17,;1.33,-5.71,;,-6.48,;4,-1.09,;4,.45,;2.67,1.22,;5.33,1.22,;5.33,2.76,;6.67,3.53,;6.67,.45,;6.67,-1.09,;8,-1.86,;9.34,-1.09,;5.33,-1.86,;5.33,-3.4,)| Show InChI InChI=1S/C28H33Cl2N5O5/c1-6-24(36)34-15-18(16-34)33(9-10-38-3)7-8-35-20-12-23(31-2)32-14-17(20)11-19(28(35)37)25-26(29)21(39-4)13-22(40-5)27(25)30/h6,11-14,18H,1,7-10,15-16H2,2-5H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Bioorg Med Chem Lett 19: 773-7 (2009) BindingDB Entry DOI: 10.7270/Q2GX4DVZ
					More data for this Ligand-Target Pair