BDBM389157 3-(2,5-dioxopyrrolidin- 3-yl)-1H-indole-6- carbonitrile::US9949951, 22

SMILES: O=C1CC(C(=O)N1)c1c[nH]c2cc(ccc12)C#N

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 389157   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM389157 (3-(2,5-dioxopyrrolidin- 3-yl)-1H-indole-6- carboni...) Show SMILES O=C1CC(C(=O)N1)c1c[nH]c2cc(ccc12)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assay				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM389157 (3-(2,5-dioxopyrrolidin- 3-yl)-1H-indole-6- carboni...) Show SMILES O=C1CC(C(=O)N1)c1c[nH]c2cc(ccc12)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Tampere					Assay Description The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...				J Med Chem 52: 646-54 (2009) BindingDB Entry DOI: 10.7270/Q2959KW7
					More data for this Ligand-Target Pair