BDBM390017 4-amino-1-[(3R)-1-[(E)-4- [cyclopropyl(ethyl)amino]but-2- enoyl]-3-piperidyl]-3-(4- phenoxyphenyl)-6H-pyrrolo[2,3- d]pyridazin-7-one::US10323037, Example 30::US9951077, 30

SMILES: CCN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C1CC1

InChI Key: InChIKey=BISJGPVNIVTMLX-QQRRWSATSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390017   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390017 (4-amino-1-[(3R)-1-[(E)-4- [cyclopropyl(ethyl)amino...) Show SMILES CCN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C1CC1 Show InChI InChI=1S/C32H36N6O3/c1-2-36(23-14-15-23)18-7-11-28(39)37-19-6-8-24(20-37)38-21-27(29-30(38)32(40)35-34-31(29)33)22-12-16-26(17-13-22)41-25-9-4-3-5-10-25/h3-5,7,9-13,16-17,21,23-24H,2,6,8,14-15,18-20H2,1H3,(H2,33,34)(H,35,40)/b11-7+/t24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	505	n/a	n/a	n/a	n/a	n/a	n/a
JIANGSU HENGRUI MEDICINE CO., LTD. US Patent					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				US Patent US10323037 (2019) BindingDB Entry DOI: 10.7270/Q2W098BW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390017 (4-amino-1-[(3R)-1-[(E)-4- [cyclopropyl(ethyl)amino...) Show SMILES CCN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C1CC1 Show InChI InChI=1S/C32H36N6O3/c1-2-36(23-14-15-23)18-7-11-28(39)37-19-6-8-24(20-37)38-21-27(29-30(38)32(40)35-34-31(29)33)22-12-16-26(17-13-22)41-25-9-4-3-5-10-25/h3-5,7,9-13,16-17,21,23-24H,2,6,8,14-15,18-20H2,1H3,(H2,33,34)(H,35,40)/b11-7+/t24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	505	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				Bioorg Med Chem Lett 17: 3972-7 (2007) BindingDB Entry DOI: 10.7270/Q2MG7RV0
					More data for this Ligand-Target Pair