BindingDB logo
myBDB logout

null

SMILES: FC(F)(F)c1cccc(n1)C(=O)Nc1cc2cn(CC(=O)N3CCOCC3)nc2cc1OCC1CC1

InChI Key: InChIKey=UMGIYCAXYWPXOW-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 390155   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM390155
PNG
(US9951086, Example 47)
Show SMILES FC(F)(F)c1cccc(n1)C(=O)Nc1cc2cn(CC(=O)N3CCOCC3)nc2cc1OCC1CC1
Show InChI InChI=1S/C24H24F3N5O4/c25-24(26,27)21-3-1-2-17(28-21)23(34)29-19-10-16-12-32(13-22(33)31-6-8-35-9-7-31)30-18(16)11-20(19)36-14-15-4-5-15/h1-3,10-12,15H,4-9,13-14H2,(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



GSK



Assay Description
For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM solution of the test substance in DMSO....

Bioorg Med Chem Lett 17: 3972-7 (2007)


BindingDB Entry DOI: 10.7270/Q2GQ713M
More data for this
Ligand-Target Pair