BDBM391293 4-((1-(4-(cyanomethyl)-1- (cyclopropylsulfonyl)piperidin- 4-yl)-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-3-yl)amino)-N,N- dimethylbenzenesulfonamide::US9957264, Example 14-2

SMILES: CN(C)S(=O)(=O)c1ccc(Nc2nn(c3cc[nH]c(=O)c23)C2(CC#N)CCN(CC2)S(=O)(=O)C2CC2)cc1

InChI Key: InChIKey=LEPDKKSIRCQPDJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391293   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM391293 (4-((1-(4-(cyanomethyl)-1- (cyclopropylsulfonyl)pip...) Show SMILES CN(C)S(=O)(=O)c1ccc(Nc2nn(c3cc[nH]c(=O)c23)C2(CC#N)CCN(CC2)S(=O)(=O)C2CC2)cc1 Show InChI InChI=1S/C24H29N7O5S2/c1-29(2)37(33,34)18-5-3-17(4-6-18)27-22-21-20(9-14-26-23(21)32)31(28-22)24(10-13-25)11-15-30(16-12-24)38(35,36)19-7-8-19/h3-6,9,14,19H,7-8,10-12,15-16H2,1-2H3,(H,26,32)(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				Bioorg Med Chem Lett 19: 360-4 (2009) BindingDB Entry DOI: 10.7270/Q2KH0QN8
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM391293 (4-((1-(4-(cyanomethyl)-1- (cyclopropylsulfonyl)pip...) Show SMILES CN(C)S(=O)(=O)c1ccc(Nc2nn(c3cc[nH]c(=O)c23)C2(CC#N)CCN(CC2)S(=O)(=O)C2CC2)cc1 Show InChI InChI=1S/C24H29N7O5S2/c1-29(2)37(33,34)18-5-3-17(4-6-18)27-22-21-20(9-14-26-23(21)32)31(28-22)24(10-13-25)11-15-30(16-12-24)38(35,36)19-7-8-19/h3-6,9,14,19H,7-8,10-12,15-16H2,1-2H3,(H,26,32)(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				Bioorg Med Chem Lett 19: 360-4 (2009) BindingDB Entry DOI: 10.7270/Q2KH0QN8
					More data for this Ligand-Target Pair