BDBM391525 2-cyclopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]pyridin-4- yl)-2H-1,4-benzoxazin-3(4H)- one::US10472358, Example 23::US9957268, Example 23

SMILES: COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CC1

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 391525   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [342-460] (Homo sapiens (Human))	BDBM391525 (2-cyclopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-dih...) Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CC1 Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				J Med Chem 52: 1081-99 (2009) BindingDB Entry DOI: 10.7270/Q29Z977H
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM391525 (2-cyclopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-dih...) Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				US Patent US10472358 (2019) BindingDB Entry DOI: 10.7270/Q2FN18KH
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM391525 (2-cyclopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-dih...) Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				US Patent US10472358 (2019) BindingDB Entry DOI: 10.7270/Q2FN18KH
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM391525 (2-cyclopropyl-6-methoxy-8- (6-methyl-7-oxo-6,7-dih...) Show SMILES COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C1CC1 Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				J Med Chem 52: 1081-99 (2009) BindingDB Entry DOI: 10.7270/Q29Z977H
					More data for this Ligand-Target Pair