null

SMILES: Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O

InChI Key: InChIKey=AOCBNYMNFJBMMG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 391555   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM391555 (2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...) Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				J Med Chem 52: 1081-99 (2009) BindingDB Entry DOI: 10.7270/Q29Z977H
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [342-460] (Homo sapiens (Human))	BDBM391555 (2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...) Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				J Med Chem 52: 1081-99 (2009) BindingDB Entry DOI: 10.7270/Q29Z977H
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [342-460] (Homo sapiens (Human))	BDBM391555 (2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...) Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM391555 (2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...) Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				US Patent US10781209 (2020)
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [42-168] (Homo sapiens (Human))	BDBM391555 (2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...) Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM391555 (2,2-dimethyl-8-(6-methyl-7- | US10781209, Example ...) Show SMILES Cn1cc(-c2cc(cc3NC(=O)C(C)(C)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O Show InChI InChI=1S/C19H19N3O5S/c1-19(2)18(24)21-14-8-10(28(4,25)26)7-12(16(14)27-19)13-9-22(3)17(23)15-11(13)5-6-20-15/h5-9,20H,1-4H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...				US Patent US10781209 (2020)
					More data for this Ligand-Target Pair