null
SMILES: CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCC2)C(=O)NCC(C)(C)O)c(Cl)c1Cl
InChI Key: InChIKey=UATOMOTUFXJSPU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human)) | BDBM392169 (US10301272, Example 21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding to RORγ was performed as follows: DNA encodin... | J Med Chem 52: 1814-27 (2009) BindingDB Entry DOI: 10.7270/Q2S184TJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human)) | BDBM392169 (US10301272, Example 21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-... | J Med Chem 52: 1814-27 (2009) BindingDB Entry DOI: 10.7270/Q2S184TJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human)) | BDBM392169 (US10301272, Example 21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L... | J Med Chem 52: 1814-27 (2009) BindingDB Entry DOI: 10.7270/Q2S184TJ | |||||||||||
More data for this Ligand-Target Pair |