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SMILES: N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCCNC2)n1

InChI Key: InChIKey=PVAQJGAOCRZJQX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392728   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (Human))		BDBM392728
PNG
(Example 28 | US10301291, Compound 14d)
Show SMILES N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCCNC2)n1
Show InChI InChI=1S/C24H23N7/c25-11-9-21-16-28-23(19-8-7-17-4-1-2-5-18(17)14-19)31(21)22-10-13-27-24(30-22)29-20-6-3-12-26-15-20/h1-2,4-5,7-8,10,13-14,16,20,26H,3,6,9,12,15H2,(H,27,29,30)
PDB
MMDB

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n/an/a<30n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...

J Med Chem 52: 1994-2005 (2009)


BindingDB Entry DOI: 10.7270/Q20K2BW1
More data for this
Ligand-Target Pair